研发中心概况 

      博鸿研发中心位于南京雨花经济开发区, 占地共1000平方米, 具备小试及公斤级生产的标准化实验室和仪器设备，配备完善的质量检测仪器，拥有一流的研发队伍和先进的实验设备，主要从事新型医药中间体，材料单体的研发，原料药合成工艺及其技术和工艺流程改进，同时还提供从毫克级到公斤级规模的定制合成服务。研发中心可以按客户需求完成各种低温（-80℃）、高温（300℃）、高压氢化等反应，尤其在嘧啶、吡啶、喹啉、噻吩及有机硼酸类化合物的合成方面，博鸿在国内同行业中处于领先水平。

Introduction of R&D center

     R&D center of Yield, located in Nanjing Yuhua Economic Development Zone and covering  about 1,000 square meters, is equipped with a QC room, standardized labs and professional apparatus used for R&D and scale-up kilogram synthesis.It is mainly engaged in synthetic technology research and process development as well as custom synthesis of pharmaceutical intermediates，electronic compounds and API from milligrams to grams. The center can finish various kinds of reactions, such as reactions in low temperature（-80℃）and high temperature（300℃）, hydrogenation reactions and so on. Especially in synthesizing primidine, pyridine, thiophene, quinoline and boronic acid, Yield lies at the leading level in China.

仪器设备  研发中心目前具备完善的药物及其中间体开发、公斤级生产的一系列标准化实验室及仪器设备，包括20升旋转蒸发仪，高压氢化釜，50升反应釜，精馏塔等。此外，我们还具备完善的质量检测仪器（高效液相色谱及气相色谱）。

Apparatus

    R&D center has standardized labs and a QC room for HPLC and GC. The labs are equipped with professional apparatus used for R&D and scale-up kilogram synthesis for intermediates and APIs, including 20L Rotary Evaporators, 50L reactor, high-prssure hydrogenation reactor and rectifying tower, etc.

数 据 库

      博鸿拥有Scifinder、Beilstein、Reaxys、以及公司内部数据库等。

Database

质量保证与控制

       博鸿建立了完善的产品质量保证体系，把质量做为公司发展之根本，秉承“质量第一”的原则，凭借先进的分析仪器及丰富的分析经验，确保每批产品的质量达到客户的要求。
       在实验进程中，项目负责人主要负责技术步骤全程监控和操作；实验开始前由技术总监亲自对所有实验员，特别是项目负责人作技术路线指导,确保相关人员都能熟悉该实验的流程,避免发生错误。最终产品送入研发中心内的质检室进行抽样检测，并为客户提供详细的质量检测报告。

Quality Control

      Yield views quality as the basis of the whole company, and established a sound quality-guarantee system of products. A project leader is responsible for the supervising and operation during the whole technical procedure. Before the beginning of a project the CTO gives instructions on the synthesis route to all participating persons, especially the project leader, in order to familiarize them with the procedure and emphasis is given in order to avoid possible mistakes.
      A systematic set of analysis apparatus and regulations is available in Yield's laboratories to verify the chemical structure and to decide whether the compound is in the contracted range of purity. With the help of advanced instruments and professional analysts, all compounds provided by Yield can satisfy its clients'needs.

服务以及专利

   博鸿在整个研发和生产过程中都注重诚信。知识产权是公司以及客户最宝贵的财富。我们在实验开始前与客户和员工都签有保密协议，严格按照保密协议的条款来提供文献检索、合成路线设计、合成、分析等服务，为客户在最短的时间内提供目标化合物。此外，我们还建立了严格的文件管理体系来保护客户的信息, 包括实验室记录册的每日签名以及定期的文件整理工作。
      交货质优，及时提供产品分析证明;完整的批次记录以及样品存档。

Service and Patent protection

     We deal with every part of our work with the highest integrity no matter how small it is within a whole development and manufacturing process. Intellectual property is the most important asset of our company as well as our clients. We have confidential agreement with not only customers before project conduction but also employees before work in Lab. We also establish rigorous documentation system to safeguard customers’ IP including daily-signature of lab notebook and regular filing of all involved documents.
     Delivery on time with qualified goods and COA; Integrate batch enregister and sample saving.